Can L Glutamine Cause Acne

Can L-Glutamine Cause Acne?

L-Glutamine is an amino acid that is produced naturally in the body. It is also available as a dietary supplement. L-Glutamine is often used to improve athletic performance, boost the immune system, and reduce inflammation. Recently, there has been some interest in using L-Glutamine to treat acne.

How Does L-Glutamine Work?

L-Glutamine is thought to work in several ways to improve acne. First, it may help to reduce inflammation. Inflammation is a key factor in the development of acne. L-Glutamine is converted to glutamic acid in the body. Glutamic acid is a precursor to gamma-aminobutyric acid (GABA), which is a neurotransmitter that has anti-inflammatory effects.

Second, L-Glutamine may help to regulate sebum production. Sebum is an oily substance that is produced by the sebaceous glands in the skin. Excess sebum can clog pores and lead to acne. L-Glutamine may help to reduce sebum production by inhibiting the activity of the sebaceous glands. This may not apply specifically to acne and more research needs to be done on the connection.

Third, L-Glutamine may help to improve the skin’s barrier function. A healthy skin barrier is essential for preventing acne. L-Glutamine may help to strengthen the skin’s barrier function by increasing the production of ceramides and fatty acids. Ceramides and fatty acids are important components of the skin’s natural barrier.

Is There any Evidence that L-Glutamine can Help with Acne?

Several studies have looked at the potential of L-Glutamine for treating acne. Some studies have shown that L-Glutamine can be helpful in reducing acne lesions, while other studies have not found any benefit. For example, one study of 60 people with acne found that taking 2 grams of L-Glutamine per day for 8 weeks significantly reduced the number of acne lesions. Another study of 40 people with acne found that taking 3 grams of L-Glutamine per day for 12 weeks did not have any effect on acne lesions.

Is L-Glutamine Safe for Everyone?

L-Glutamine is generally considered to be safe for most people. However, there are some people who should not take L-Glutamine, including people with kidney disease, liver disease, and people who are pregnant or breastfeeding. L-Glutamine may also interact with some medications, so it is important to talk to your doctor before taking L-Glutamine if you are taking any medications.


There is some evidence that L-Glutamine may be helpful in treating acne. However, more research is needed to confirm the effectiveness of L-Glutamine for acne. If you are considering taking L-Glutamine for acne, it is important to talk to your doctor first.